Gene

mcm2

ID
ZDB-GENE-020419-24
Name
minichromosome maintenance complex component 2
Symbol
mcm2 Nomenclature History
Previous Names
  • cb737 (1)
  • chunp6905
  • MCM2 minichromosome maintenance deficient 2
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Exhibits chromatin binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Involved in regulation of cilium assembly; retina development in camera-type eye; and thymus development. Predicted to localize to MCM complex and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Is expressed in several structures, including hindbrain neural rod; midbrain neural rod; optic vesicle; paraxial mesoderm; and thymus. Orthologous to human MCM2 (minichromosome maintenance complex component 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mcm2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 70 Alliance ?Deafness, autosomal dominant 70 616968
Associated With mcm2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018525 Mini-chromosome maintenance, conserved site
Domain IPR001208 MCM domain
Domain IPR027925 MCM N-terminal domain
Domain IPR033762 MCM OB domain
Domain IPR041562 MCM, AAA-lid domain
Family IPR008045 DNA replication licensing factor Mcm2
Family IPR031327 Mini-chromosome maintenance protein
Homologous_superfamily IPR012340 Nucleic acid-binding, OB-fold
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length DNA replication licensing factor Mcm2 MCM, AAA-lid domain MCM domain MCM N-terminal domain MCM OB domain Mini-chromosome maintenance, conserved site Mini-chromosome maintenance protein Nucleic acid-binding, OB-fold P-loop containing nucleoside triphosphate hydrolase
UniProtKB:Q7ZUR0 889
UniProtKB:A0A0R4IF65 889
UniProtKB:Q8JGR5 880
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mcm2 polyclonal IgG1 Rabbit
  • WB
BD Biosciences
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations