Gene
angpt1
- ID
- ZDB-GENE-010817-1
- Name
- angiopoietin 1
- Symbol
- angpt1 Nomenclature History
- Previous Names
-
- ang1 (1)
- wu:fc76g06
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Is predicted to enable receptor tyrosine kinase binding activity. Involved in Tie signaling pathway and angiogenesis. Acts upstream of or within blood vessel development and brain development. Is expressed in several structures, including brain; cardiovascular system; hypochord; medial longitudinal fasciculus; and ventral mesenchyme. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
?Angioedema, hereditary, 5 | 619361 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR020837 | Fibrinogen, conserved site |
Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
Family | IPR028843 | Angiopoietin-1 |
Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
Domain Details Per Protein
Protein | Length | Angiopoietin-1 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen, conserved site | Fibrinogen-like, C-terminal |
---|---|---|---|---|---|---|
UniProtKB:Q90Z19
|
513 | |||||
UniProtKB:B3DJK2
|
513 | |||||
UniProtKB:Q1MT43
|
513 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
angpt1-201
(1)
|
2164 nt |
Interactions and Pathways
No data available
Plasmids
No data available