Gene

angpt1

ID

ZDB-GENE-010817-1

Name

angiopoietin 1

Symbol

angpt1 Nomenclature History

Previous Names

ang1 (1)
wu:fc76g06

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Is predicted to enable receptor tyrosine kinase binding activity. Involved in Tie signaling pathway and angiogenesis. Acts upstream of or within blood vessel development and brain development. Is expressed in several structures, including brain; cardiovascular system; hypochord; medial longitudinal fasciculus; and ventral mesenchyme. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 14 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With angpt1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Angioedema, hereditary, 5	619361

Associated With angpt1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020837	Fibrinogen, conserved site
Domain	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
Family	IPR028843	Angiopoietin-1
Homologous_superfamily	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
Homologous_superfamily	IPR036056	Fibrinogen-like, C-terminal