Gene
bcl2l1
- ID
- ZDB-GENE-010730-1
- Name
- BCL2 like 1
- Symbol
- bcl2l1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in extrinsic apoptotic signaling pathway in absence of ligand and intrinsic apoptotic signaling pathway in response to DNA damage. Acts upstream of or within negative regulation of apoptotic process; thyroid gland development; and tissue homeostasis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including blood island; endocrine system; extension; immune system; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1021 (10 images)
- IMAGE:6910760 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Porreca et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Apoptosis regulator, Bcl-2, BH1 motif, conserved site | Apoptosis regulator, Bcl-2 protein, BH4 | Apoptosis regulator, Bcl-X | Bcl2-like |
|---|---|---|---|---|---|
|
UniProtKB:Q90Z98
|
238 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
bcl2l1-201
(1)
|
2025 nt | |
| mRNA |
bcl2l1-202
(1)
|
1979 nt |
Interactions and Pathways
No data available
Plasmids
No data available