Gene

bcl2l1

ID

ZDB-GENE-010730-1

Name

BCL2 like 1

Symbol

bcl2l1 Nomenclature History

Previous Names

bcl-XL (1)
bcl2l
cb1021 (1)
zfBLP1 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway; thyroid gland development; and tissue homeostasis. Predicted to be located in several cellular components, including mitochondrion; nuclear membrane; and synaptic vesicle membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including blood island; endocrine system; extension; immune system; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); and pancreatic cancer. Orthologous to human BCL2L1 (BCL2 like 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

27 figures from 18 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb1021 (10 images)
IMAGE:6910760 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Porreca et al., 2012
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bcl2l1 Human Ortholog

No data available

Associated With bcl2l1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site
Domain	IPR003093	Apoptosis regulator, Bcl-2 protein, BH4
Domain	IPR046371	Bcl-2, Bcl-2 homology region 1-3
Family	IPR002475	Bcl2-like
Family	IPR013279	Apoptosis regulator, Bcl-X
Family	IPR026298	Bcl-2 family
Homologous_superfamily	IPR036834	Bcl-2-like superfamily