ZFIN is now using GRCz12tu for Genomic Data
Gene
or42c3
- ID
- ZDB-GENE-010308-14
- Name
- odorant receptor, family 42, subfamily C, member 3
- Symbol
- or42c3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable odorant binding activity and olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to act upstream of or within sensory perception of smell. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in olfactory epithelium and olfactory receptor cell. Orthologous to several human genes including OR1E1 (olfactory receptor family 1 subfamily E member 1); OR1E2 (olfactory receptor family 1 subfamily E member 2); and OR1E3 (olfactory receptor family 1 subfamily E member 3 (gene/pseudogene)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Saraiva et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Olfactory receptor | Olfactory receptor 51/52/56-like |
|---|---|---|---|---|---|---|
| UniProtKB:O42169 | InterPro | 325 | ||||
| UniProtKB:Q2PRC8 | InterPro | 325 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
or111-6-201
(1)
|
Ensembl | 1,477 nt | ||
| mRNA |
or111-6-202
(1)
|
Ensembl | 1,024 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-133D24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195352 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:195353 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131746 (1) | 978 nt | ||
| Genomic | GenBank:AL845428 (1) | 157787 nt | ||
| Polypeptide | UniProtKB:O42169 (1) | 325 aa |
No data available
- Behrens, M., Di Pizio, A., Redel, U., Meyerhof, W., Korsching, S.I. (2020) At the root of T2R gene evolution: Recognition profiles of coelacanth and zebrafish bitter receptors. Genome biology and evolution. 13(1)
- Olender, T., Jones, T.E.M., Bruford, E., Lancet, D. (2020) A unified nomenclature for vertebrate olfactory receptors. BMC Evolutionary Biology. 20:42
- Saraiva, L.R., Ahuja, G., Ivandic, I., Syed, A.S., Marioni, J.C., Korsching, S.I., Logan, D.W. (2015) Molecular and neuronal homology between the olfactory systems of zebrafish and mouse. Scientific Reports. 5:11487
- Ferreira, T., Wilson, S.R., Choi, Y.G., Risso, D., Dudoit, S., Speed, T.P., Ngai, J. (2014) Silencing of Odorant Receptor Genes by G Protein βγ Signaling Ensures the Expression of One Odorant Receptor per Olfactory Sensory Neuron. Neuron. 81(4):847-59
- Ng, Y.K., Wu, W., and Zhang, L. (2009) Positive correlation between gene coexpression and positional clustering in the zebrafish genome. BMC Genomics. 10:42
- Niimura, Y. (2009) On the Origin and Evolution of Vertebrate Olfactory Receptor Genes: Comparative Genome Analysis Among 23 Chordate Species. Genome biology and evolution. 1:34-44
- Alioto, T.S., and Ngai, J. (2005) The odorant receptor repertoire of teleost fish. BMC Genomics. 6:173
- Niimura, Y., and Nei, M. (2005) Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods. Proceedings of the National Academy of Sciences of the United States of America. 102(17):6039-6044
- Kratz, E., Dugas, J.C., and Ngai, J. (2002) Odorant receptor gene regulation: implications from genomic organization. Trends in genetics : TIG. 18(1):29-34
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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