PUBLICATION
Noncoordinate expression of odorant receptor genes tightly linked in the zebrafish genome
- Authors
- Barth, A.L., Dugas, J.C., and Ngai, J.
- ID
- ZDB-PUB-971003-2
- Date
- 1997
- Source
- Neuron 19(2): 359-369 (Journal)
- Registered Authors
- Barth, Alison, Ngai, John
- Keywords
- none
- MeSH Terms
-
- Genetic Linkage/genetics*
- Genome*
- Male
- Animals
- Receptors, Odorant/genetics*
- In Situ Hybridization
- Amino Acid Sequence
- Zebrafish/genetics*
- Molecular Sequence Data
- PubMed
- 9292725 Full text @ Neuron
Citation
Barth, A.L., Dugas, J.C., and Ngai, J. (1997) Noncoordinate expression of odorant receptor genes tightly linked in the zebrafish genome. Neuron. 19(2):359-369.
Abstract
We have characterized the organization and expression of odorant receptor genes clustered within approximately 100 kb of the zebrafish genome. Physical analysis of this genomic region reveals that the receptor genes are tightly linked in tandem arrays. The expression patterns of these genes were evaluated during development as well as in the adult olfactory epithelium. Highly related genes from this array are expressed individually in different olfactory neurons, suggesting that the discriminatory capacity of the vertebrate olfactory system has been maximized by segregating the most similar receptors into distinct cellular pathways. Furthermore, genes from this cluster are activated at different times of development. Together, these results indicate that genomically linked odorant receptor genes are not coordinately regulated.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping