Gene

ctsd

ID

ZDB-GENE-010131-8

Name

cathepsin D

Symbol

ctsd Nomenclature History

Previous Names

etID16901.18 (1)
LAP (1)
wu:fb93e11 (1)
wu:fj17b09 (1)

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have aspartic-type endopeptidase activity. Involved in muscle structure development; response to bacterium; and retinal pigment epithelium development. Predicted to localize to lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Is expressed in several structures, including eye; liver; muscle; pleuroperitoneal region; and unfertilized egg. Orthologous to human CTSD (cathepsin D).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

14 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:55226 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctsd Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
neuronal ceroid lipofuscinosis 10	Alliance	Ceroid lipofuscinosis, neuronal, 10	610127

Associated With ctsd Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR001969	Aspartic peptidase, active site
Domain	IPR012848	Aspartic peptidase, N-terminal
Domain	IPR033121	Peptidase family A1 domain
Family	IPR001461	Aspartic peptidase A1 family
Family	IPR033144	Cathepsin D
Homologous_superfamily	IPR021109	Aspartic peptidase domain superfamily

Domain Details Per Protein

Protein	Length	Aspartic peptidase A1 family	Aspartic peptidase, active site	Aspartic peptidase domain superfamily	Aspartic peptidase, N-terminal	Cathepsin D	Peptidase family A1 domain
UniProtKB:Q8AWD9 InterPro	398

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	ctsd-202 (1) Ensembl	Havana	799 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctsd-201 (1) Ensembl	Havana	1784 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	ctsd-003 (1) Ensembl	Havana	635 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab2-ctsd	monoclonal	ctsd	IgG2a	Mouse	WB	BD Biosciences	1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations