Gene
oprm1
- ID
- ZDB-GENE-010125-1
- Name
- opioid receptor, mu 1
- Symbol
- oprm1 Nomenclature History
- Previous Names
-
- ZfMOR (1)
- ZFOR2
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Enables G protein-coupled enkephalin receptor activity and morphine receptor activity. Predicted to be involved in G protein-coupled opioid receptor signaling pathway; neuropeptide signaling pathway; and sensory perception of pain. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including nervous system; notochord; otic vesicle; prechordal plate; and trunk. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; drug dependence (multiple); drug psychosis; and withdrawal disorder (multiple). Orthologous to human OPRM1 (opioid receptor mu 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | Mu opioid receptor | Opioid receptor |
|---|---|---|---|---|---|---|
| UniProtKB:B8JHS2 | InterPro | 382 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-160H10 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194866 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131707 (1) | 1476 nt | ||
| Genomic | GenBank:CR352246 (2) | 87130 nt | ||
| Polypeptide | UniProtKB:B8JHS2 (1) | 382 aa |
- Bian, Y., Wang, X., Liang, J.H., Li, L., Wu, X., Tang, B., Leung, G.P., Lee, S.M. (2021) The development of behavioral sensitization induced by a single morphine exposure in adult zebrafish (Danio rerio). Progress in neuro-psychopharmacology & biological psychiatry. 113:110456
- Chen, Z., Zhijie, C., Yuting, Z., Chan, L., Shilin, X., Qichun, Z., Jinying, O., Jing, L., Chaohua, L., Zhixian, M. (2021) The Ameliorative Effects of Isorhynchophylline on Morphine Dependence Are Mediated Through the Microbiota-Gut-Brain Axis. Frontiers in pharmacology. 12:526923
- Chen, Z., Zhijie, C., Yuting, Z., Shilin, X., Qichun, Z., Jinying, O., Chaohua, L., Jing, L., Zhixian, M. (2020) Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish. Frontiers in microbiology. 11:946
- Sivalingam, M., Ogawa, S., Parhar, I.S. (2020) Mapping of Morphine-Induced OPRM1 Gene Expression Pattern in the Adult Zebrafish Brain. Frontiers in Neuroanatomy. 14:5
- Arévalo, J.C., Hernández-Jiménez, E., Jiménez-González, A., Torres-Valle, M., Iwasaki, R.S., López-Bellido, R., Vicente-García, C., Rodríguez, R.E. (2018) Generation and Characterization of Antibodies against Opioid Receptors from Zebrafish. International Journal of Molecular Sciences. 19(1)
- Thörnqvist, P.O., McCarrick, S., Ericsson, M., Roman, E., Winberg, S. (2018) Bold zebrafish (Danio rerio) express higher levels of delta opioid and dopamine D2 receptors in the brain compared to shy fish. Behavioural brain research. 359:927-934
- Rosa, M., Gonzalez-Nunez, V., Barreto-Valer, K., Marcelo, F., Sánchez-Sánchez, J., Calle, L.P., Arévalo, J.C., Rodríguez, R.E., Jiménez-Barbero, J., Arsequell, G., Valencia, G. (2017) Role of the sugar moiety on the opioid receptor binding and conformation of a series of enkephalin neoglycopeptides. Bioorganic & Medicinal Chemistry. 25(7):2260-2265
- Garcia-Concejo, A., Jimenez-Gonzalez, A., Rodríguez, R.E. (2016) μ Opioid Receptor Expression after Morphine Administration Is Regulated by miR-212/132 Cluster. PLoS One. 11:e0157806
- Jimenez-Gonzalez, A., García-Concejo, A., López-Benito, S., Gonzalez-Nunez, V., Arévalo, J.C., Rodriguez, R.E. (2016) Role of morphine, miR-212/132 and mu opioid receptor in the regulation of bdnf in zebrafish embryos. Biochimica et biophysica acta. General subjects. 1860(6):1308-16
- Parker, M.O., Evans, A.M., Brock, A.J., Combe, F.J., Teh, M.T., Brennan, C.H. (2016) Moderate alcohol exposure during early brain development increases stimulus-response habits in adulthood. Addiction biology. 21(1):49-60
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