Gene
ctsk
- ID
- ZDB-GENE-001205-4
- Name
- cathepsin K
- Symbol
- ctsk Nomenclature History
- Previous Names
-
- etID33526.16 (1)
- wu:fa95f03
- wu:fb08b05
- zgc:110367
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Is predicted to enable cysteine-type endopeptidase activity. Involved in immune response and proteolysis involved in cellular protein catabolic process. Acts upstream of or within bone development; cartilage development; and response to mechanical stimulus. Predicted to be located in apical plasma membrane and extracellular region. Is expressed in several structures, including cardiovascular system; head; lateral line system; mesoderm; and pectoral fin. Human ortholog(s) of this gene implicated in pycnodysostosis. Orthologous to human CTSK (cathepsin K).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 23 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110367 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Flanagan-Steet et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pycnodysostosis | Alliance | Pycnodysostosis | 265800 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Active_site | IPR025660 | Cysteine peptidase, histidine active site |
| Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
| Domain | IPR000668 | Peptidase C1A, papain C-terminal |
| Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
| Domain | IPR039417 | Papain-like cysteine endopeptidase |
| Family | IPR015644 | Peptidase C1A, cathepsin K |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A, cathepsin K | Peptidase C1A, papain C-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q568D6
|
333 | ||||||||
|
UniProtKB:F8QXP3
|
284 | ||||||||
|
UniProtKB:F1Q8A0
|
333 | ||||||||
|
UniProtKB:F8QXP4
|
284 |
Interactions and Pathways
No data available
Plasmids
No data available