Gene
vtg1
- ID
- ZDB-GENE-001201-1
- Name
- vitellogenin 1
- Symbol
- vtg1 Nomenclature History
- Previous Names
-
- vg1
- zfvg1 (1)
- zgc:109796
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Enables antioxidant activity. Acts upstream of or within several processes, including cellular response to estrogen stimulus; hatching; and response to estradiol. Is expressed in several structures, including adipose tissue; atrium; liver; pleuroperitoneal region; and unfertilized egg.
- Genome Resources
- Note
-
vtg1-201 is a transcript described in ZDB-PUB-180609-20 and matches ENSDART00000078276 (Zv9) and corresponds to the partial cDNA clone with sequence BC094995.
- Comparative Information
-
- All Expression Data
- 55 figures from 39 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Yilmaz et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001747 | Vitellogenin, N-terminal |
| Domain | IPR015255 | Vitellinogen, open beta-sheet |
| Domain | IPR015258 | Vitellinogen, beta-sheet shell |
| Family | IPR050733 | Vitellogenin/Apolipophorin |
| Homologous_superfamily | IPR011030 | Lipovitellin-phosvitin complex, superhelical domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Lipid transport protein, beta-sheet shell | Lipovitellin-phosvitin complex, superhelical domain | Vitellinogen, beta-sheet N-terminal | Vitellinogen, beta-sheet shell | Vitellinogen, beta-sheet shell domain superfamily | Vitellinogen, open beta-sheet | Vitellinogen, open beta-sheet, subdomain 1 | Vitellogenin/Apolipophorin | Vitellogenin, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q1LWN2 | InterPro | 1362 | |||||||||
| UniProtKB:A0A8M3AME1 | InterPro | 1347 |
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- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-23D18 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:109796 | ||
| Encodes | cDNA | MGC:174137 | ZFIN Curated Data | |
| Has Artifact | EST | fb63b05 | ||
| Has Artifact | EST | fb63d05 | ||
| Has Artifact | EST | fb64d12 | ||
| Has Artifact | EST | fb65b06 | ||
| Has Artifact | EST | fb67a10 | ||
| Has Artifact | EST | fb68e07 | ||
| Has Artifact | EST | fd55c06 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001044897 (1) | 4431 nt | ||
| Genomic | GenBank:BX248330 (1) | 189880 nt | ||
| Polypeptide | UniProtKB:Q1LWN2 (1) | 1362 aa |
- Liu, Z., Zhang, N., Wang, C., Shi, L., Hu, Y., Wang, Y., Li, J. (2024) Lrp13a and Lrp13b serve as vitellogenin receptors in the ovary of zebrafish†. Biology of reproduction. 111(1):123-134
- Peng, W., Zhang, Y., Song, B., Yang, P., Liu, L. (2024) Developmental Delay and Male-Biased Sex Ratio in esr2b Knockout Zebrafish. Genes. 15(5):
- Uju, C., Karimzadeh, K., Unniappan, S. (2024) Brain Derived Neurotrophic Factor Stimulates Hypothalamic and Gonadal Reproductive Hormones and Oocyte Maturation in Zebrafish. Reproduction (Cambridge, England). 169(1):
- Zhu, B., Zhang, Z., Pardeshi, L., Chen, Y., Ge, W. (2024) Role of Y box-binding protein 1 (Ybx1) in zebrafish folliculogenesis: Promoting follicle cell proliferation via suppression of p21 (cdkn1a). Development (Cambridge, England). 151(21):
- Medkova, D., Hollerova, A., Blahova, J., Marsalek, P., Mares, J., Hodkovicova, N., Doubkova, V., Hesova, R., Tichy, F., Faldyna, M., Taştan, Y., Kotoucek, J., Svobodova, Z., Lakdawala, P. (2023) Medicine designed to combat diseases of affluence affects the early development of fish. How do plastic microparticles contribute?. The Science of the total environment. 904:166378
- Ramachandran, D., Sharma, K., Saxena, V., Nipu, N., Rajapaksha, D.C., Mennigen, J.A. (2023) Knock-out of vasotocin reduces reproductive success in female zebrafish, Danio rerio. Frontiers in endocrinology. 14:11512991151299
- Sun, S.X., Liu, Y.C., Limbu, S.M., Li, D.L., Chen, L.Q., Zhang, M.L., Yin, Z., Du, Z.Y. (2023) Vitellogenin 1 is essential for fish reproduction by transporting DHA-containing phosphatidylcholine from liver to ovary. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(4):159289
- Yilmaz, O., Com, E., Pineau, C., Bobe, J. (2023) Genomic disturbance of vitellogenin 2 (vtg2) leads to vitellin membrane deficiencies and significant mortalities at early stages of embryonic development in zebrafish (Danio rerio). Scientific Reports. 13:1879518795
- Zhai, Y., Zhang, X., Zhao, C., Geng, R., Wu, K., Yuan, M., Ai, N., Ge, W. (2023) Rescue of bmp15 deficiency in zebrafish by mutation of inha reveals mechanisms of BMP15 regulation of folliculogenesis. PLoS Genetics. 19:e1010954e1010954
- Boland, R., Heemskerk, M.T., Forn-Cuní, G., Korbee, C.J., Walburg, K.V., Esselink, J.J., Carvalho Dos Santos, C., de Waal, A.M., van der Hoeven, D.C.M., van der Sar, E., de Ries, A.S., Xie, J., Spaink, H.P., van der Vaart, M., Haks, M.C., Meijer, A.H., Ottenhoff, T.H.M. (2022) Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis. mBio. 14(1):e0302422
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