Gene

tnnt2a

ID
ZDB-GENE-000626-1
Name
troponin T type 2a (cardiac)
Symbol
tnnt2a Nomenclature History
Previous Names
  • ctnnt (1)
  • cTnT
  • tnnt2
  • sih
  • silent heart
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to contribute to calcium-dependent ATPase activity and tropomyosin binding activity. Involved in several processes, including animal organ development; circulatory system development; and nitric oxide biosynthetic process. Localizes to troponin complex. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Is expressed in cardiac muscle; cardiovascular system; and mesoderm. Orthologous to human TNNT2 (troponin T2, cardiac type).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
29 figures from 21 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
97 figures from 62 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tnnt2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
dilated cardiomyopathy 1D Alliance Cardiomyopathy, dilated, 1D 601494
dilated cardiomyopathy 1D Alliance Left ventricular noncompaction 6 601494
hypertrophic cardiomyopathy 2 Alliance Cardiomyopathy, hypertrophic, 2 115195
restrictive cardiomyopathy 3 Alliance Cardiomyopathy, familial restrictive, 3 612422
Associated With tnnt2a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR001978 Troponin
Family IPR027707 Troponin T
Homologous_superfamily IPR038077 Troponin domain superfamily
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tnnt2 monoclonal IgG Mouse
  • IHC
Developmental Studies Hybridoma Bank
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations