ZFIN Fish: s356tTg

ZFIN ID: ZDB-FISH-150901-21109

ZFIN ID: ZDB-FISH-150901-21109

Fish name:	s356tTg
Genotype:	s356tTg
Targeting Reagent:	none

HUMAN DISEASE MODELED by s356tTg

Human Disease	Conditions	Citations
drug-induced hearing loss	chemical treatment by environment: cisplatin	Hu et al., 2020

GENE EXPRESSION
Gene expression in s356tTg

RNA expression

Expressed Gene	Structure	Conditions	Figures
baxa	whole organism	control	Fig 6 from Zhang et al., 2020
cabp2b	inner ear hair cell neuromast	standard conditions	Fig. 5 from Di Donato et al., 2013
casp3a	whole organism	control	Fig 6 from Zhang et al., 2020
casp9	whole organism	control	Fig 6 from Zhang et al., 2020
cep104	inner ear	standard conditions	Fig. 1 from Di Stazio et al., 2020
cntn2	retinal ganglion cell axon	control	Fig. 7 from Diekmann et al., 2009
dclk1a	(not) inner ear	standard conditions	Fig. 1 from Di Stazio et al., 2020
neurog1	(not) inner ear	control	Fig. 3 from Sapède et al., 2012
nherf1a	hematopoietic system inner ear hair cell liver	standard conditions	Fig. 3 from Girotto et al., 2019
pcdh20	inner ear	standard conditions	Fig. 1 from Di Stazio et al., 2020
pi4kb	auditory receptor cell apical plasma membrane	standard conditions	Fig. 5 from Feng et al., 2020
prox1a	neuromast somatic stem cell neuromast hair cell	standard conditions	Fig. 1 , Fig. 2 from Pistocchi et al., 2009
rho	retinal rod cell	control	Fig. 7 from Diekmann et al., 2009
slc44a2	inner ear	standard conditions	Fig. 1 from Di Stazio et al., 2020
strn	inner ear	standard conditions	Fig. 1 from Di Stazio et al., 2020
tp53	whole organism	control	Fig 6 from Zhang et al., 2020

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab2-ctbp2l		regenerating tissue synaptic ribbon	chemical treatment by environment: neomycin	Fig. 5 from Suli et al., 2016
Ab1-ctbp2l		neuromast hair cell ribbon synapse	standard conditions	Fig. 1 , Fig. 6 from Faucherre et al., 2010
zrf-3		optic tectum	standard conditions	Fig. 1 from Gosse et al., 2009
Ab10-sox2		neuromast support cell	control	Fig. 3 from Gao et al., 2018
Ab-5E11		amacrine cell	control	Fig. 7 from Diekmann et al., 2009
Ab4-GFP		anterior lateral line neuromast hair cell	control	Fig. 5 from Suli et al., 2016
Ab4-GFP		regenerating tissue neuromast hair cell	chemical treatment by environment: neomycin	Fig. 5 from Suli et al., 2016
zpr-1		photoreceptor cell	standard conditions	Fig. 1 from Jing et al., 2009
Ab2-ctbp2l		neuromast hair cell synaptic ribbon	control	Fig. 5 from Suli et al., 2016
Ab1-cntn2	cntn2	retinal ganglion cell axon	control	Fig. 7 from Diekmann et al., 2009
Ab1-pi4kb	pi4kb	auditory receptor cell apical plasma membrane	standard conditions	Fig. 5 from Feng et al., 2020
Ab3-prox1	prox1a	neuromast somatic stem cell neuromast hair cell	standard conditions	Fig. 1 , Fig. 2 from Pistocchi et al., 2009
Ab1-rho	rho	retinal rod cell	control	Fig. 7 from Diekmann et al., 2009

Reporter gene expression

Expressed Gene	Structure	Conditions	Figures
EGFP	posterior lateral line neuromast hair cell posterior lateral line neuromast saccule hair cell utricle hair cell	standard conditions	Fig. 4, Fig. 8 from He et al., 2020 Fig. 2 from Wang et al., 2018 Fig. 1 from Stobb et al., 2012
GFP	anterior crista anterior lateral line neuromast hair cell anterior lateral line neuromast anterior macula auditory receptor cell caudal tuberculum cranial nerve II eye hair cell hair cell anterior macula hair cell posterior macula immature hair cell anterior macula immature hair cell posterior macula inner ear hair cell lateral crista macula saccule hair cell Mauthner neuron medial longitudinal fasciculus neuromast neuromast hair cell optic chiasm optic tectum optic tract otic placode otic sensory epithelium otic vesicle hair cell posterior crista posterior lateral line neuromast hair cell posterior lateral line neuromast neuromast hair cell posterior macula retinal ganglion cell axon tectal neuropile	standard conditions	56 figures from 36 publications
	anterior lateral line neuromast hair cell hair cell neuromast neuromast hair cell otic vesicle hair cell (not) posterior lateral line neuromast	chemical treatment by environment: cisplatin	13 figures from 8 publications
	neuromast hair cell regenerating tissue neuromast hair cell	physical alteration: anatomical structure, chemical treatment: neomycin sulfate	Fig. 1 from He et al., 2014

PHENOTYPE
Phenotype in s356tTg

Phenotype	Conditions	Figures
anterior lateral line neuromast has extra parts of type neuromast hair cell, abnormal	chemical treatment: pharmaceutical	Fig. 6 from Jacques et al., 2014
hair cell regeneration process quality, normal	chemical treatment by environment: neomycin	Fig. 6 from Kim et al., 2018
hair cell anterior macula disorganized, abnormal	standard conditions	Fig. 1 from Millimaki et al., 2010
hair cell anterior macula protruding out of macula utricle, abnormal	standard conditions	Fig. 1 from Millimaki et al., 2010
inner ear receptor cell development increased duration, abnormal	standard conditions	Fig. 1 from Millimaki et al., 2010
macula has extra parts of type hair cell, abnormal	chemical treatment: all-trans-retinoic acid	Fig. 8 from Maier et al., 2014
macula has fewer parts of type hair cell, abnormal	chemical treatment: 4-(diethylamino)benzaldehyde	Fig. 8 from Maier et al., 2014
macula utricle has fewer parts of type hair cell, abnormal	standard conditions	Fig. 1 from Millimaki et al., 2010
neuromast lacks parts or has fewer parts of type neuromast hair cell, abnormal	chemical treatment: ethanol	Fig. 2 from Uribe et al., 2013
neuromast apoptotic process increased occurrence, abnormal	chemical treatment: neomycin	Fig. 3 from Rah et al., 2015
neuromast apoptotic process increased occurrence, ameliorated	chemical treatment: drug, chemical treatment: neomycin	Fig. 3 from Rah et al., 2015
neuromast cell death increased occurrence, abnormal	chemical treatment: ethanol	Fig. 4 from Uribe et al., 2013
neuromast cell population proliferation decreased occurrence, abnormal	chemical treatment: ethanol	Fig. 3 from Uribe et al., 2013
neuromast kinocilium disorganized, abnormal	chemical treatment by environment: neomycin	Fig. 5 from Chang et al., 2016
neuromast kinocilium morphology, ameliorated	chemical treatment by environment: neomycin, chemical treatment by environment: sodium selenate	Fig. 5 from Chang et al., 2016
neuromast stereocilium disorganized, abnormal	chemical treatment by environment: neomycin	Fig. 5 from Chang et al., 2016
neuromast stereocilium morphology, ameliorated	chemical treatment by environment: neomycin, chemical treatment by environment: sodium selenate	Fig. 5 from Chang et al., 2016
neuromast hair cell amount, ameliorated	chemical treatment by environment: neomycin, chemical treatment by environment: sodium selenate	Fig. 2 , Fig. 4 from Chang et al., 2016
neuromast hair cell apoptotic, abnormal	chemical treatment by environment: neomycin	Fig. 3 from Chang et al., 2016
neuromast hair cell damaged, abnormal	chemical treatment by environment: neomycin	Fig. 4 , Fig. 6 from Chang et al., 2016
neuromast hair cell decreased amount, abnormal	chemical treatment by environment: neomycin	Fig. 2 , Fig. 4 from Chang et al., 2016
neuromast hair cell decreased amount, abnormal	chemical treatment: neomycin	Fig. 1, Fig. 2 from Rah et al., 2015
neuromast hair cell decreased amount, abnormal	chemical treatment by environment: cisplatin	Fig. 1 from Hu et al., 2020
neuromast hair cell GFP expression decreased amount, abnormal	chemical treatment by environment: cisplatin	Fig. 1 from Hu et al., 2020
neuromast hair cell decreased amount, abnormal	chemical treatment: tranylcypromine hydrochloride	Fig. 1 from He et al., 2013
neuromast hair cell decreased amount, ameliorated	chemical treatment: drug, chemical treatment: neomycin	Fig. 1, Fig. 2 from Rah et al., 2015
neuromast hair cell decreased functionality, abnormal	chemical treatment: ethanol	Fig. 2 from Uribe et al., 2013
neuromast hair cell morphology, ameliorated	chemical treatment by environment: neomycin, chemical treatment by environment: sodium selenate	Fig. 4 , Fig. 6 from Chang et al., 2016
neuromast hair cell apoptotic process increased occurrence, abnormal	chemical treatment by environment: neomycin	Fig. 3 from Chang et al., 2016
neuromast hair cell apoptotic process process quality, ameliorated	chemical treatment by environment: neomycin, chemical treatment by environment: sodium selenate	Fig. 3 from Chang et al., 2016
neuromast hair cell cytoplasm degenerate, abnormal	chemical treatment by environment: neomycin	Fig. 6 from Chang et al., 2016
neuromast hair cell mitochondrion swollen, abnormal	chemical treatment by environment: neomycin	Fig. 6 from Chang et al., 2016
neuromast hair cell nucleus condensed, abnormal	chemical treatment by environment: neomycin	Fig. 6 from Chang et al., 2016
neuromast hair cell regeneration decreased occurrence, abnormal	physical alteration: anatomical structure, chemical treatment: valproic acid, chemical treatment: neomycin sulfate	Fig. 1 from He et al., 2014
neuromast hair cell regeneration decreased occurrence, abnormal	physical alteration: anatomical structure, chemical treatment: trichostatin A, chemical treatment: neomycin sulfate	Fig. 1 from He et al., 2014
otic vesicle hair cell amount, abnormal	chemical treatment: SU5402	Fig. 2 from Maier et al., 2014
otic vesicle hair cell amount, ameliorated	chemical treatment by environment: alpha-cyano-4-hydroxycinnamic acid, chemical treatment by environment: lactate	Figure 5 from Kantarci et al., 2020
otic vesicle hair cell amount, ameliorated	chemical treatment by environment: 2-deoxy-D-glucose, chemical treatment by environment: lactate	Figure 5 from Kantarci et al., 2020
otic vesicle hair cell amount, ameliorated	chemical treatment by environment: enzyme inhibitor, chemical treatment by environment: lactate	Figure 5 from Kantarci et al., 2020
otic vesicle hair cell decreased amount, abnormal	chemical treatment by environment: alpha-cyano-4-hydroxycinnamic acid	Figure 5 from Kantarci et al., 2020
otic vesicle hair cell decreased amount, abnormal	chemical treatment by environment: enzyme inhibitor	Figure 5 from Kantarci et al., 2020
otic vesicle hair cell decreased amount, abnormal	chemical treatment by environment: 2-deoxy-D-glucose	Figure 5 from Kantarci et al., 2020
otic vesicle hair cell disorganized, abnormal	chemical treatment: SU5402	Fig. 2 from Maier et al., 2014
otolith position, abnormal	chemical treatment: SU5402	Fig. 2 from Maier et al., 2014
otolith regeneration process quality, normal	chemical treatment by environment: neomycin	Fig. 6 from Kim et al., 2018

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