FIGURE

FIGURE 4

ID

ZDB-FIG-251216-22

Publication

Chen et al., 2025 - Ddx3xa mutations drive cardiac defects in a zebrafish model via dysregulation of wnt/β-catenin signaling

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FIGURE 4

Malformation rate quantification and validation of ddx3xa knockout efficiency in zebrafish. (A) Malformation rate in ddx3xa^−/− zebrafish at 48 hpf (**P < 0.01 vs. wild-type). (B) qRT-PCR analysis of ddx3xa mRNA levels in 72-hpf embryos showing significant downregulation in mutants (n = 3; *P < 0.05, ***P < 0.001). (C) Representative Western blot of Ddx3xa protein expression in 72-hpf larvae. Gapdh served as a loading control. (D) Quantitative densitometric analysis of Ddx3xa protein levels in wild-type and ddx3xa^−/− larvae at 72 hpf.

Expression Data

Gene:	ddx3xa
Fish:	AB ddx3xa^hn102/hn102 (AB)
Anatomical Term:	whole organism
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ddx3xa^hn102/hn102 (AB)
Observed In:	whole organism
Stage Range:	Long-pec to Protruding-mouth

Phenotype Detail

Acknowledgments

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