FIGURE

Fig. 6

ID

ZDB-FIG-251006-47

Publication

Mendoza et al., 2025 - Role of DENN Domain-Containing Protein 5b (dennd5b) during early embryonic development of zebrafish

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Fig. 6

dennd5b plays a role in CE movement. Zebrafish embryos at the one-cell stage were injected with dennd5b MO, and dennd5b mRNA. These embryos were either viewed from the dorsal side, ventral side and or laterally. a-c The angle between the anterior-most and the posterior-most ends of the body axis was measured (scale bar, 420 μm). d-a′ Knockdown or overexpression of dennd5b affects the expression of CE movement-related genes as determined by WISH. The expression pattern of the neuroectoderm marker dlx3b, notochord marker tbxta, somite marker myod1 and rhombomere 3,5 of the hindbrain marker krox20 were determined at 7–8 somite stage (12 hpf). The expression pattern of the prechordal plate marker ctslb was determined at 1–3 somite stage (10–11 hpf) scale bar 500 μm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-dennd5b
Knockdown Reagent:	MO1-dennd5b
Observed In:	convergent extension mesendoderm migration neural plate notochord prechordal plate rhombomere 3 rhombomere 5 somite
Stage Range:	1-4 somites to 5-9 somites

Phenotype Detail

Acknowledgments

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