Fig. 2

Cmpk2 deficiency aggravates P. aeruginosa-induced acute lung injury in mice A Survival analysis of WT/KO mice after i.t. administration of P. aeruginosa (1 × 107 CFU per mouse, n = 10 mice per group). B-C Representative images (B) and quantification of pathology scores (C) of lung tissue sections stained with H&E at 24 h post P. aeruginosa infection (1 × 106 CFU/ 50 μL PBS). Scale bars in the upper panel, 1 mm; scale bars in the lower panel, 100 µm (n = 7 mice per group). D-E Production of IL-1β (D), IL-6 (E) in BALF was evaluated by ELISA. F Total protein levels in BALF. G Quantification of weight loss. H The bacteria count in the BALF of mice. Each data point represents an individual mouse (D-H). *P < 0.05, ****P < 0.0001 (by two-tailed unpaired t-test)