FIGURE

Fig. 6

ID

ZDB-FIG-250422-99

Publication

Iegiani et al., 2025 - CITK modulates BRCA1 recruitment at DNA double strand breaks sites through HDAC6

Other Figures

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Fig. 6

Targeting HDAC6 recovers microcephaly in MCPH17 Zebrafish model.

a Schematic representation of the experiment performed. b Representative brightfield images of the head region of 24 hpf embryos showing normal or reduced head size. Scalebar = 100 μm. c Quantification of the lateral head area under control conditions, after injection of cita-LoF morpholino oligonucleotide and after co-injection of cita-LoF with control vector or Cit-K expression vector. d Quantification of the lateral head area under control conditions and in cita-LoF embryos treated with DMSO or Tubastin A at the indicated concentrations. e Quantification of the lateral head area under control condition of after injection of the indicated morpholinos. Each dot indicates a single embryo. Error bars, SEM. *P < 0.05, ***P < 0.001, ****P < 0.0001 one-way ANOVA test followed by Tukey’s correction.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-cita + MO2-cita AB + MO1-cita + MO1-hdac6 + MO2-cita
Condition:	chemical treatment by environment: tubastatin A
Knockdown Reagents:	MO1-cita MO1-hdac6 MO2-cita
Observed In:	head
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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