FIGURE

Fig 9

ID

ZDB-FIG-250321-17

Publication

Nonarath et al., 2025 - The USH3A causative gene clarin1 functions in Müller glia to maintain retinal photoreceptors

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Fig 9

Expression of N-cadherin is reduced in clrn1^-/- zebrafish.

Confocal microscope images of N-cadherin immunostaining in transverse cryosections of retinas from 7 dpf (a) wild-type, (b) clrn1^-/-, and (c) clrn1^-/-Tg(gfap:Clrn1^low). Images of N-cadherin staining in the OLM (a’, b’, c’) were generated by rotating projected Z-stacks 90˚at the level of the OLM. The OLM and RPE are denoted to the left of panel (a). Yellow asterisks in (b) indicate delocalized N-cadherin within the inner nuclear layer. (d) Quantitation of N-cadherin fluorescence intensity from 300 um² central retinal regions revealed that N-cadherin staining was reduced in clrn1^-/- but not in clrn1^-/-; gfap:Clrn1^low (n=12 eyes each genotype). (e) N-Cadherin ring diameter frequency distribution for each genotype. Example measurements marked by yellow lines. Date points in (e) represent 35 rings scored in 300 um² central retina region (n = 12 eyes each genotype). (****p<0.001; One-way ANOVA). Error bars=SD. Scale Bar=10 mm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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