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Fig. 5

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ZDB-FIG-250310-13

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Guo et al., 2024 - Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish

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Fig. 5

Wnt2bb controls pharyngeal chondrocyte maturation by activating β-catenin dependent signaling pathway. A and B: wnt2bb−/− embryos with a Tg(fli1:EGFP) background were treated with 10 μM BIO or 10 μM HLY78 from 28 hpf, and collected for Alcian blue staining (A) and live imaging (B) at 5 dpf, respectively. 3D reconstruction of chondrocytes (B) in ceratohyal cartilages was performed using Imaris software. The dotted lines and asterisks represent individual cells subjected to in-depth analysis via 3D reconstruction. C: The volume of individual chondrocytes in ceratohyal cartilages was quantified via Imaris (n = 7). ∗∗∗, P < 0.001; ns, not significant (student's t-test). WT, wild-type; m, Meckel's cartilage; ep, ethmoid plate; pq, palatoquadrate; hs, hyosymplectic; ch, ceratohyal; cbs, ceratobranchial cartilages; dpf, days post fertilization. Scale bars, 100 μm (A); 20 μm (B).

Expression Data

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Antibody Labeling

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Reprinted from Journal of genetics and genomics = Yi chuan xue bao, , Guo, X., Yang, L., Wang, Y., Yuan, M., Zhang, W., He, X., Wang, Q., Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish, , Copyright (2024) with permission from Elsevier. Full text @ J. Genet. Genomics