FIGURE

Fig. 1

ID

ZDB-FIG-250207-56

Publication

Della Vecchia et al., 2025 - Dapagliflozin ameliorates Lafora disease phenotype in a zebrafish model

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Fig. 1

(A) Schedule of treatment with gliflozins. (B) Analysis of the effects of gliflozins on coiling behaviour of epm2a^−/− and WT embryos at 30 hpf. The experiments were performed in triplicate. The number of larvae in each group ranges from a minimum of 40 to a maximum of 300. The graphs represent the median and standard error of the mean (SEM). (C) Analysis of the effects of gliflozins on locomotion (distance travelled and velocity) in epm2a^−/− and WT larvae at 5 dpf. The experiments were performed in triplicate. The number of larvae in each group ranges from a minimum of 40 to a maximum of 300. The graphs represent the median and SEM. Statistical analysis was performed using the Kruskal-Wallis test. Dunn’s test was used to perform post-hoc analysis for multiple comparisons after the Kruskal-Wallis test. (**** p ≤ 0.0001; ***p ≤ 0.001; **p ≤ 0.01; *p ≤ 0.05). Non-significant comparisons are not reported.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	epm2a^{zf3794/zf3794} (AB)
Conditions:	chemical treatment by environment: canagliflozin chemical treatment by environment: dapagliflozin chemical treatment by environment: empagliflozin
Observed In:	swimming swimming behavior
Stage Range:	Prim-15 to Day 5

Phenotype Detail

Acknowledgments

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