FIGURE

Fig. 2

ID

ZDB-FIG-241017-32

Publication

Armistead et al., 2024 - A sphingolipid rheostat controls apoptosis versus apical cell extrusion as alternative tumour-suppressive mechanisms

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Fig. 2

Cell death in hai1a^fr26 mutants is caspase-dependent and tp53-independent.

a–h Apoptotic cells in the caudal fin fold of 4 dpf embryos, immunostained for aCasp3 (red), p63 (green) and DAPI (blue), with tp53 mutation or upon treatment with ZDEVD-FMK to inhibit apoptosis. Scale bar = 50 μm. i Quantification of the numbers of aCasp3-positive cells in the tail fins of embryos, normalised to fin area. Means were compared using one-way ANOVA with post-hoc Tukey’s multiple comparison test. j Survival curves showing the effects of tp53 mutation or ZDEVD-FMK treatment on embryo viability.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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