FIGURE

Figure 4

ID

ZDB-FIG-240607-123

Publication

Fabian et al., 2024 - Comprehensive phenotypic characterization of an allelic series of zebrafish models of NEB-related nemaline myopathy

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Figure 4

Swimming behaviour is defective in neb mutants. Muscle performance and function in neb mutants was assessed by tracking optovin-induced swimming of embryos at 7 dpf. Graphs showing time spent moving, distance travelled, and speed for each zebrafish line. The nonsense mutants neb¹⁵ and neb¹¹ showed significantly shorter time swimming, distance travelled, and lower speed compared to their siblings. The splice mutants neb³⁴ and neb²¹, with mutations in SR region, also showed significantly shorter time spent swimming. The motor behaviour of the splice mutant neb³⁰ is not significantly different from that recorded for its siblings. Graphs display values normalized to wt (mean ± SEM). Asterisks indicate p-values (* ≤ 0.05; ** ≤ 0.01; *** ≤ 0.001; **** ≤ 0.0001). See Supplemental Table 3 for descriptive statistics.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	neb^{sa11973/sa11973} neb^{sa15371/sa15371} neb^{sa21475/sa21475} neb^{sa30646/sa30646} neb^{sa34628/sa34628}
Condition:	chemical treatment by environment: optovin, visible light
Observed In:	swimming swimming behavior
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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