FIGURE

Fig 3

ID
ZDB-FIG-240531-146
Publication
Inoue et al., 2024 - Biallelic variants in LARS1 induce steatosis in developing zebrafish liver via enhanced autophagy
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Fig 3

Larsb-knockin larvae display liver abnormality during the liver developmental stage. A Diagram showing the larsb genomic locus and larsb-knockin (larsb-I451F) zebrafish mutant genotype. B In the genomic sequencing analysis chromatograms, the mutation site in the larsb-I451F zebrafish is shown in red. C Morphological abnormality at 4 to 7 dpf in the livers of larsb-I451F larvae with a Tg[fabp10:mcherry] background. White arrows indicate the loss of liver edges in larsb-I451F larvae. Scale bar: 200 μm. D Relative liver area in larsb-WT (n = 15 fish) and larsb-I451F (n = 9 fish) larvae with a Tg[fabp10:mcherry] background (4 to 7 dpf). *P < 0.05. E Circularity of liver in larsb-WT (n = 15 fish) and larsb-I451F (n = 9 fish) larvae with a Tg[fabp10:mcherry] background (4 to 7 dpf). Error bars indicate SEM. *P < 0.05, **P < 0.01
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage Range: Day 5 to Days 7-13

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Orphanet J Rare Dis
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