FIGURE

Fig. 2

ID

ZDB-FIG-240422-25

Publication

Pontius et al., 2024 - Magnetically powered microwheel thrombolysis of occlusive thrombi in zebrafish

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Fig. 2

Time to fibrinolysis after infusion of tPA. The PCV of 3 dpf larvae was injured, producing a completely occluding thrombus. This was followed by either no infusion/uninjected (n = 54), infusion of saline (n = 17), 1 ng of recombinant human tPA (n = 16), or 10 ng of recombinant human tPA (n = 40), and then observation for up to 4 h. Only high concentrations of tPA at 10 ng/larvae (~5 to 10× the amount used for human therapy) were able to achieve recanalization in a fraction of larvae within 4 h and without significant toxicity. Lower concentrations of tPA did not recanalize. Bars represent median recanalization time (*P < 0.01, ****P < 0.0001 by Mantel-Cox log-rank testing).

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA