FIGURE

Fig. 3

ID

ZDB-FIG-240130-9

Publication

Darrah et al., 2023 - Antisense Oligonucleotide Activation via Enzymatic Antibiotic Resistance Mechanism

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Fig. 3

(A) Luciferase reporter assay in which luciferase expression is silenced in the presence of linearized MO. (B) Luminescence signal after treatment of the indicated MO. Data represent average ± SEM from three independent experiments. (C) Gel-shift assay showing activation of the circular morpholino sequestering its complementary target DNA (cDNA) in the presence of β-lactamase. (D) Quantification of a time course analysis of cyclic cephalosporin ntla cMO cleavage following incubation with recombinant β-lactamase. Bars represent averages and error bars represent standard deviations from three independent experiments.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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