FIGURE

Fig. 7

ID

ZDB-FIG-240130-54

Publication

Kozol et al., 2023 - Drugs prescribed for Phelan-McDermid syndrome differentially impact sensory behaviors in shank3 zebrafish models

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Fig. 7

PTZ exposure does not induce seizure-like behavior in shank3 mutants. a) Behavioral traces of larvae exposed to 3 mM PTZ. b) Activity of WT, shank3ab N and shank3ab C larvae for 10 minutes following exposure to 3 mM of PTZ. Box plots: box represents 25th and 75th percentile, and median, with min to max whiskers. Sample sizes for shank3 N trials, WT = 30, shank3 N = 30; for shank3 C trials, WT = 31, shank3 C = 28. p values; * = p < 0.05, ** = p < 0.01, *** = p < 0.001, **** = p < 0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TL shank3a^{umi101/umi101}; shank3b^{umi102/umi102} (AB/TL) shank3a^{zf3839/zf3839}; shank3b^{zf3840/zf3840} (AB/TL)
Condition:	chemical treatment by environment: pentetrazol
Observed In:	swimming behavior
Stage:	Day 6

Phenotype Detail

Acknowledgments

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