FIGURE

Fig. 4

ID

ZDB-FIG-231003-19

Publication

Bradshaw et al., 2023 - Zebrafish as a model for cardiac disease; Cryo-EM structure of native cardiac thin filaments from Danio Rerio

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Fig. 4

Conformation of troponin core domain and tropomyosin positions. The high and low Ca²⁺ models 6KN8 (green) and 6KN7 (blue) were docked into our thin filament reconstruction and compared to our zebrafish model (yellow). A & B: the core domains of Tn1 and Tn2. Regions of empty density are indicated with *. B: ɑ (45°) & (35°) the angle the TnI helix 1 makes with the horizontal in the two states C & D: the tropomyosin overlap region where TnT1 domain is located of Tn1 and Tn2 respectively. E,F, & G: Pairwise comparison of the position of tropomyosin from the three models

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Muscle Res. Cell Motil.