FIGURE

Fig. 4

ID

ZDB-FIG-230925-12

Publication

Dal Forno et al., 2023 - Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C-C Bond Cleavage Reactions

Other Figures

All Figure Page

Back to All Figure Page

Fig. 4

Toxicity of Propargyl-Lap (2) compared to β-lapachone for cancer cell lines measured by CellTiter Blue assay. (A) SKBR3 cell viability for 72 h. (B) Cell viability of SKBR3 cells after treatment with Propargyl-Lap (2) and subsequent decaging efficiency upon treatment with Pd(0)-NPs or PdI₂-NPs, after 72 h (C) MOLM13 cell viability for 48 h. (D) Cell viability of MOLM13 cells after treatment with Propargyl-Lap (2) and subsequent decaging efficiency upon treatment with PdI₂-NPs, after 48 h. Cell viability was determined by CellTiter Blue assay. The statistical significance: **P ≤ 0.01, ***P ≤ 0.001, and ****P ≤ 0.0001. Each experiment was performed in technical triplicates and two biological experiments. Error bars represent the standard error of the mean. Cells were treated with increasing concentrations of 2 and β-Lap during 48 h, after which the cell viability was determined using the CellTiter Blue assay. IC₅₀ values were calculated from the generated eight-point semilog dose–response curves.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Am. Chem. Soc.