FIGURE

Figure 4

ID

ZDB-FIG-230731-5

Publication

Sun et al., 2023 - lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway

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Figure 4

Phenotypic replication and behavioral tests of lmo4a KO embryos. All panels of photos represent lateral views of ears. (A–H) Otic morphology of lmo4a KO embryos at different stages displaying smaller otocysts and thicker otic epithelia compared to WT. (I) Statistical analysis confirmed that the otocyst size of lmo4a KO group was significantly smaller at 31, 48, 72 hpf and 15 dpf (*** p < 0.001, n = 20). (J) Swimming paths of WT and lmo4a KO zebrafish were tracked, showing a more active pattern in the KO group. (K,L) The frequencies of both clockwise rotation and counterclockwise rotation were significantly higher in the KO group (* p < 0.05, n = 4).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TU + CRISPR1-lmo4a + CRISPR2-lmo4a + CRISPR3-lmo4a + CRISPR4-lmo4a
Knockdown Reagents:	CRISPR1-lmo4a CRISPR2-lmo4a CRISPR3-lmo4a CRISPR4-lmo4a
Observed In:	inner ear otic epithelium
Stage Range:	Prim-15 to Days 14-20

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Genes (Basel)