FIGURE

Fig. 5

ID

ZDB-FIG-230617-40

Publication

Sveinsdóttir et al., 2022 - Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD

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Fig. 5

Motility and sleep effects of I1 receptor agonist LNP599.

adgrl3.1^−/− larvae were treated with five different concentrations (0.1 µM, 1 µM, 10 µM, 30 µM, and 100 µM) of LNP599 and compared to larvae treated with 0.3% DMSO. Average distance moved during the five 30-min periods of lights-on and sleep parameters during the night were analyzed. LNP599 reduced the distance moved during lights-on significantly in a dose dependent manner for 10 µM, 30 µM, and 100 µM. LNP599 significantly altered all sleep parameters at various concentrations. Wild type (WT) larvae treated with DMSO are included for visual comparison. * denote significant differences.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	adgrl3.1^{zf3892/zf3892} (AB)
Conditions:	chemical treatment by environment: pyrroline lighting conditions chemical treatment by environment: pyrroline, lighting conditions
Observed In:	locomotory behavior sleep
Stage:	Day 6

Phenotype Detail

Acknowledgments

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