FIGURE

FIGURE 3

ID

ZDB-FIG-230228-107

Publication

Boyd et al., 2023 - Clcf1/Crlf1a-mediated signaling is neuroprotective and required for Müller glia proliferation in the light-damaged zebrafish retina

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FIGURE 3

The CNTFR ligands clcf1 and crlf1a are detected within Müller glia following injury, consistent with scRNA-seq data. (A–H")Maximum projection images of dark-adapted albino; Tg[gfap:EGFP] ^nt11 zebrafish that were light-treated for up to 36 h, with in situ hybridization performed utilizing either clcf1 (A–D") or crlf1a (E–H") probes. Sections were also labeled for GFP and PCNA to assess proliferating Müller glia and nuclei were counterstained with DAPI. Yellow boxes in (A-H) represent areas chosen for greater magnification (in A'-H' and A"-H"). Magenta arrowheads (D, H) show resting Müller glia. ONL, outer nuclear layer, INL, inner nuclear layer, GCL, ganglion cell layer. Scale bar represents 20 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol