FIGURE

Figure 7

ID

ZDB-FIG-221020-90

Publication

Liu et al., 2022 - Understanding the Function and Mechanism of Zebrafish Tmem39b in Regulating Cold Resistance

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Figure 7

Effects of Tmem39b dysfunction on endoplasmic reticulum stress response and autophagy. (A) A complex heatmap indicating the transcriptional expression of genes involved in endoplasmic reticulum stress response (red) and autophagy (blue). The genes were up-regulated at certain time points upon cold exposure or recovery under a normal temperature. The left part of the heatmap indicates the results of a previous study and the right part displays the data of this study. The rows of the heatmap represent genes and the columns show the averaged expression of the genes during different conditions. The row Z scores are calculated separately for the two experiments. Expression of representative genes involved in ER stress response (B) and autophagy (C) are determined by qPCR. *, p ≤ 0.05; **, p ≤ 0.01; ***, p ≤ 0.001; #, p ≤ 0.05 (n = 4). “#” indicates significant difference in gene expression between WT and zko3151b under the same condition.

Expression Data

Genes:	atf4a atf6 atg2b atg9b fbxo32 hspa5 smcr8b xbp1 (all 8)
Fish:	AB tmem39b^{zko3151b/zko3151b} (AB)
Conditions:	cold exposure cold exposure, temperature exposure
Anatomical Term:	whole organism
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB tmem39b^{zko3151b/zko3151b} (AB)
Conditions:	cold exposure cold exposure, temperature exposure
Observed In:	whole organism
Stage:	Day 4

Phenotype Detail

Acknowledgments

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