FIGURE

Fig. 6

ID

ZDB-FIG-220912-66

Publication

Moret et al., 2022 - Biodegradable nanoparticles combining cancer cell targeting and anti-angiogenic activity for synergistic chemotherapy in epithelial cancer

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Fig. 6

Vasculature analysis of fli1a:EGFP embryos after two days of treatment with nanoparticles (NPs) ([DTX] = 2.5 ng/animal). Fluorescence microscopy images of untreated embryos without (A) or with KB xenografted cells (B); embryos with KB xenografted cells and treated with free DTX (C) or DTX-DBL_Fol/aFLT1 (D). B1 is a magnification showing the presence of vascular branches (white circles) sprouting toward tumor masses in untreated embryos. In the magnification, D1 vascular branches are not visible due to the anti-angiogenic effect exerted by DTX-DBL_Fol/aFLT1. Scale bar: 250 μm. Red: tumor cells stained with DiI; green: zebrafish embryo vasculature

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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