FIGURE

Fig. 2.

ID

ZDB-FIG-220317-9

Publication

Serrano et al., 2021 - Novel pre-clinical model for CDKL5 Deficiency Disorder

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2.

Motor function and muscle pathology in cdkl5^−/− fish. (A-C) Quantification of normalized distance travelled (A), speed (B) and time active (C) of cdkl5^+/+, cdkl5^+/− and cdkl5^−/− fish at 6 dpf. Data are mean±s.e.m. for three independent experiments (n=38, 21 and 15 for cdkl5^+/+; n=17, 39 and 19 for cdkl5^+/−; and n=27, 25 and 14 for cdkl5^−/− fish per experiment). *P<0.05; ****P<0.0001; NS, not significant (one-way ANOVA). (D) Maximum intensity projection of a confocal image series of α-myosin and α-Actinin2 antibody staining of cdkl5^+/+ and cdkl5^−/− fish at 2 dpf. (E) Maximum intensity projections of confocal images of α-myosin antibody staining of cdkl5^+/+ and cdkl5^−/− fish at 6 dpf. Scale bars: 100 µm (D); 10 µm (E).

Expression Data

Antibodies:	Ab-A4.1025 Ab1-actn
Fish:	WT cdkl5^{sa21938/sa21938}
Anatomical Term:	trunk muscle cell
Stage Range:	Long-pec to Day 6

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cdkl5^{sa21938/sa21938} cdkl5^sa21938/+
Observed In:	trunk muscle cell whole organism swimming whole organism swimming behavior
Stage Range:	Long-pec to Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.