FIGURE

Fig. 1

ID

ZDB-FIG-211010-1

Publication

Zhao et al., 2021 - The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway

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Fig. 1

Decreased HSPCs in the CHT region of zebrafish <italic>smu471</italic> mutants.

A–Dcmyb WISH identified HSPCs from 2 to 4 dpf in smu471 mutants (right) compared with their siblings (left). Acmyb⁺ signals were not altered at 2 dpf in the VDA region (blue arrowheads indicate signals in the region). B In the CHT region, cmyb⁺ signals were decreased slightly at 2.5 dpf in smu471 mutants (red arrowheads indicate signals in the region). C, D Severely decreased cmyb⁺ signals in the CHT region at 3 dpf (C) with a further reduction at 4 dpf (D) in smu471 mutants. The boxed regions in the lower right corner are magnifications. Scale bars: 200 µm.

Expression Data

Gene:	myb
Fish:	WT sart3^sm471/sm471
Anatomical Terms:	caudal hematopoietic tissue hematopoietic multipotent progenitor cell caudal hematopoietic tissue hematopoietic stem cell ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ventral wall of dorsal aorta hematopoietic stem cell
Stage Range:	Long-pec to Day 4

Expression Detail

Gene	Fish	Conditions	Stage	Anatomy	Assay
myb	WT	standard conditions	Long-pec	ventral wall of dorsal aorta hematopoietic multipotent progenitor cell	ISH
myb	WT	standard conditions	Long-pec	ventral wall of dorsal aorta hematopoietic stem cell	ISH
myb	WT	standard conditions	Pec-fin	caudal hematopoietic tissue hematopoietic multipotent progenitor cell	ISH
myb	WT	standard conditions	Pec-fin	caudal hematopoietic tissue hematopoietic stem cell	ISH
myb	WT	standard conditions	Protruding-mouth	caudal hematopoietic tissue hematopoietic multipotent progenitor cell	ISH
myb	WT	standard conditions	Protruding-mouth	caudal hematopoietic tissue hematopoietic stem cell	ISH
myb	WT	standard conditions	Day 4	caudal hematopoietic tissue hematopoietic multipotent progenitor cell	ISH
myb	WT	standard conditions	Day 4	caudal hematopoietic tissue hematopoietic stem cell	ISH
myb	sart3^sm471/sm471	standard conditions	Long-pec	ventral wall of dorsal aorta hematopoietic multipotent progenitor cell	ISH
myb	sart3^sm471/sm471	standard conditions	Long-pec	ventral wall of dorsal aorta hematopoietic stem cell	ISH

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Antibody Labeling

Phenotype Data

Fish:	sart3^sm471/sm471
Observed In:	caudal hematopoietic tissue hematopoietic multipotent progenitor cell caudal hematopoietic tissue hematopoietic stem cell ventral wall of dorsal aorta hematopoietic multipotent progenitor cell ventral wall of dorsal aorta hematopoietic stem cell
Stage Range:	Long-pec to Day 4

Phenotype Detail

Acknowledgments

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