Cdan1 is required for primitive erythroid differentiation. (A) CdanΔEry erythroblasts do not demonstrate the semi-synchronous maturation characteristic of primitive erythroblasts. Quantification of erythroid sub-populations represented as mean ± SEM. Sub-population were grouped by CD71/Ter119 surface expression according to the following: I – Ter119loCD71+; II – Ter119+CD71+; III – Ter119+CD71lo. (B) Representative FACS profile of CdanΔEry peripheral blood erythroblasts compared to littermate controls.
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