FIGURE

Fig. 3

ID

ZDB-FIG-210426-31

Publication

Cinzia et al., 2021 - Therapeutic efficacy of 3,4-Diaminopyridine phosphate on neuromuscular junction in Pompe disease

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Fig. 3

3,4-Diaminopyridine phosphate improved NMJs in zebrafish embryos. (A) Electron micrographs showing a swollen and convoluted end-plate in a morphant, a normal appearing end-plate in a 3,4-DAPP treated morphant and a normal endplate in a control embryo. Note the synaptic cleft (white arrows) and active zones (black arrows). Scale bar = 2 µm. (B,C) Quantification of the percentage of NMJs presenting normal structure (B), and of acetylcholine vesicles (C), in the three experimental groups. Error bars are SEMs.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO2-gaa
Condition:	chemical treatment by environment: amifampridine
Knockdown Reagent:	MO2-gaa
Observed In:	somite cholinergic synapse somite neuromuscular junction somite synaptic vesicle
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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