FIGURE

Fig. 4

ID

ZDB-FIG-210218-118

Publication

Kontur et al., 2020 - Ythdf m⁶A Readers Function Redundantly during Zebrafish Development

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Fig. 4

Figure 4. Ythdf2 and Ythdf3 Are Redundantly Required for Zebrafish Ovary Development (A) Numbers of male and female fish of each genotype. Sibling control and double ythdf2;ythdf3 homozygotes were offspring from the same cross, depicted on top. (B) Gonad histology of double homozygous (ythdf2−/−;ythdf3−/−) and sibling control fish from the cross in (A). At 27 dpf, mutants exhibit less developed juvenile ovaries than controls. At 35 dpf, 6 sibling fish had adult ovaries and 8 had testes, while all 12 ythdf2−/−;ythdf3−/− fish had testes. I, stage I oocytes; II, stage II oocytes; triangle, apoptotic oocyte; sg, spermatogonia; sc, spermatocytes. n, replicate number with similar gonads. Scale bars, 40 μm. (C) Numbers of male and female fish of each genotype, following treatment with 17α-ethynylestradiol (EE2). Fish were from the same cross as in (A).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ythdf2^ch200/ch200; ythdf3^{ya3323/ya3323}
Condition:	chemical treatment: 17alpha-ethynylestradiol
Observed In:	female gonad development immature gonad ovary whole organism
Stage Range:	Days 21-29 to Days 30-44

Phenotype Detail

Acknowledgments

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