FIGURE

Figure 10

ID

ZDB-FIG-210206-10

Publication

Noschka et al., 2021 - Unbiased Identification of Angiogenin as an Endogenous Antimicrobial Protein With Activity Against Virulent Mycobacterium tuberculosis

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Figure 10

Angie1 is not toxic to zebrafish embryos. Zebrafish embryos were scored for mortality or altered phenotypes at 48 h post fertilization (hpf) after exposure for 24 h to Angie1 at the indicated concentrations or the negative control (PBS) or positive control [NRC-03 antimicrobial peptide, (AMP)]. Altered phenotypes include necrosis and non-lethal lysis (cytotoxicity), heart edema, reduced or absent circulation (cardiotoxicity), delayed development or malformations (developmental toxicity), and reduced or absent touch escape response (neurotoxicity). Note that Angie1 caused no significant toxicity. n = 60 embryos each group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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