FIGURE

Figure 4.

ID
ZDB-FIG-201119-11
Publication
Beckwith-Cohen et al., 2020 - Controlling horizontal cell-mediated lateral inhibition in transgenic zebrafish retina with chemogenetic tools
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Figure 4.

Chemogenetic manipulation of HCs modulates the bipolar cell light response. Application of FMRFamide had no effect on the ERG of WT zebrafish (A), but decreased the maximal b-wave amplitude in FaNaC zebrafish (B), reaching a maximum ∼40% decrease in the b-wave (C). Application of the buffer HEPES (pH 7.35) cancelled the effects of FMRFamide (C). FMRFamide response was dose dependent having an EC50 of 4.25 μm (D). Application of the agonist PSEM89S (30 μm) also caused a decrease in the maximal b-wave amplitude, but to a lesser degree (E, F).

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
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