FIGURE

Fig. 5

ID
ZDB-FIG-200813-13
Publication
Thiessen et al., 2019 - Zebrafish otolith biomineralization requires polyketide synthase
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Fig. 5

Aberrant expression of proteins involved in otolithdevelopment in csr and nco. (A) Schematic of anterior macula (AM) tethered to otolith at 27 hpf. (B) In WT, Otoconin-90 (Oc90) is expressed within the mineralized otolith, which is situated atop the otolithic membrane (Otogelin, or Otog), at 27 hpf. Scale bar = 5 μm. (C–D) Oc90 has diffuse expression within the otocyst of csr and nco. In csr and nco, Otog is localized near the apical surface of hair cells. (E–F) Expression showing hair cells in WT and nco larvae at 5dpf. Scale bar = 25 μm. (G) Quantification of hair cell numbers in the posterior and anterior macula of WT and nco(n = 4).

Expression Data
Antibodies:
Fish:
Anatomical Terms:
Stage Range: Prim-5 to Day 5

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Observed In:
Stage: Day 5

Phenotype Detail
Acknowledgments
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Reprinted from Mechanisms of Development, 157, Thiessen, K.D., Grzegorski, S.J., Chin, Y., Higuchi, L., Wilkinson, C.J., Shavit, J.A., Kramer, K.L., Zebrafish otolith biomineralization requires polyketide synthase, 1-9, Copyright (2019) with permission from Elsevier. Full text @ Mech. Dev.