FIGURE

Figure 5

ID

ZDB-FIG-200713-23

Publication

Coomer et al., 2020 - Her9/Hes4 is required for retinal photoreceptor development, maintenance, and survival

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Figure 5

Cone outer segments are abnormal in her9 mutants. Immunohistochemistry with a red-green cone antibody (Zpr1) in her9^+/+ or ^+/− (A,A′) and her9^−/− (B,B′) retinal sections. Arrowheads indicate outer segments. (C–H) Immunohistochemistry with an antibody that labels rod and double cone outer segments (Zpr3) on retinal cryosections of TαC:GFP; her9^+/+ or ^+/− (C–E) or TαC:GFP; her9^−/− mutant (F–H) larvae. (I) Cone cell counts in her9^−/− mutant larvae and their WT and heterozygous siblings (# of Cones/100 µM). WT/Het = 10 embryos; Mut = 10 embryos; t-test (p < .0001). ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; GCL, ganglion cell layer; L, lens; ON, optic nerve; OS, outer segment; IS, inner segment. Scale bar = 100 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	her9^uky2/uky2 her9^uky2/uky2; ucd1Tg
Observed In:	long double cone cell cone photoreceptor outer segment retinal cone cell retinal cone cell cone photoreceptor outer segment short double cone cell cone photoreceptor outer segment
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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