FIGURE

Figure 2

ID

ZDB-FIG-200314-18

Publication

Grzegorski et al., 2020 - Disruption of the kringle 1 domain of prothrombin leads to late onset mortality in zebrafish

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Figure 2

Direct oral anticoagulants prevent occlusive thrombus formation in zebrafish. 5 dpf larvae were exposed to chemical inhibitors of thrombin (dabigatran) and FXa (apixaban, rivaroxaban) for 24 hours. This resulted in the inability to form occlusive venous thrombi at 6 dpf in wild-type larvae following laser-mediated endothelial injury.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TL
Conditions:	chemical treatment by environment: apixaban, light damage: posterior cardinal vein chemical treatment by environment: dabigatran, light damage: posterior cardinal vein light damage: posterior cardinal vein chemical treatment by environment: rivaroxaban, light damage: posterior cardinal vein
Observed In:	blood coagulation
Stage:	Day 6

Phenotype Detail

Acknowledgments

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