FIGURE

Fig. 8.

ID

ZDB-FIG-200205-13

Publication

Clark et al., 2019 - Establishment and validation of an endoplasmic reticulum stress reporter to monitor zebrafish ATF6 activity in development and disease

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Fig. 8.

Reporter expression is activated in ALS and cone dystrophy zebrafish disease models. (A) Representative images showing that embryos injected with gnat2:OPN1MW^W177R mutant opsin have elevated 5XATF6RE:d2GFP expression in photoreceptors, which is absent in injection control embryos injected with all components except the overexpression construct. (B) Representative images showing overlap of hsp70:DsRed and 5XATF6RE:d2GFP expression in sod1 G93R mutant spinal cord, which is absent in WT sod1 control spinal cord. Scale bars: 0.02 mm (A); 0.1 mm (B).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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