ZFIN Figure: Huiting et al., 2018, Fig. 4

ZFIN ID: ZDB-FIG-191024-15

ZFIN ID: ZDB-FIG-191024-15

Huiting et al., 2018 - UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response. Leukemia 32(11):2339-2351 Full text @ Leukemia

ADDITIONAL FIGURES

EXPRESSION / LABELING:

Gene:	EGFP
Fish:	zdf6Tg ufd1l^hi3471Tg/+; zdf6Tg
Anatomical Terms:	thymus precursor T-cell lymphoblastic lymphoma/leukaemia whole organism precursor T-cell lymphoblastic lymphoma/leukaemia
Stage:	Adult

PHENOTYPE:

Fish:	zdf6Tg zdf13Tg; zdf7Tg ufd1l^hi3471Tg/+; zdf6Tg ufd1l^hi3471Tg/+; zdf13Tg; zdf7Tg
Condition:	heat shock
Observed In:	thymus thymus precursor T-cell lymphoblastic lymphoma/leukaemia whole organism precursor T-cell lymphoblastic lymphoma/leukaemia
Stage Range:	Days 45-89 to Adult

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details

Gene	Fish	Conditions	Stage	Anatomy	Assay
EGFP	ufd1l^hi3471Tg/+; zdf6Tg	standard conditions	Adult	thymus precursor T-cell lymphoblastic lymphoma/leukaemia	IFL
			Adult	whole organism precursor T-cell lymphoblastic lymphoma/leukaemia	IFL
	zdf6Tg	standard conditions	Adult	thymus precursor T-cell lymphoblastic lymphoma/leukaemia	IFL
			Adult	whole organism precursor T-cell lymphoblastic lymphoma/leukaemia	IFL

Antibody Labeling Details No data available

Phenotype Details

Fish	Conditions	Stage	Phenotype
ufd1l^hi3471Tg/+; zdf13Tg; zdf7Tg	heat shock	Days 45-89 - Adult	thymus neoplastic, ameliorated
		Days 45-89 - Adult	whole organism precursor T-cell lymphoblastic lymphoma/leukaemia increased amount, ameliorated
ufd1l^hi3471Tg/+; zdf6Tg	standard conditions	Adult	thymus neoplastic, ameliorated
		Adult	thymus precursor T-cell lymphoblastic lymphoma/leukaemia EGFP expression amount, ameliorated
		Adult	whole organism precursor T-cell lymphoblastic lymphoma/leukaemia EGFP expression amount, ameliorated
		Adult	whole organism precursor T-cell lymphoblastic lymphoma/leukaemia increased amount, ameliorated
zdf13Tg; zdf7Tg	heat shock	Days 45-89 - Adult	thymus neoplastic, abnormal
		Days 45-89 - Adult	whole organism precursor T-cell lymphoblastic lymphoma/leukaemia increased amount, abnormal
zdf6Tg	standard conditions	Adult	thymus neoplastic, abnormal
		Adult	thymus precursor T-cell lymphoblastic lymphoma/leukaemia EGFP expression increased amount, abnormal
		Adult	whole organism precursor T-cell lymphoblastic lymphoma/leukaemia EGFP expression increased amount, abnormal
		Adult	whole organism precursor T-cell lymphoblastic lymphoma/leukaemia increased amount, abnormal

Full text @ Leukemia