Figure 1

Different modes of collective cell migration. (A) Chain migration of neural crest cells. Cells start as a cohesive cluster at the neural plate border and then delaminate away and migrate as chains toward the Cxcl12a source. Cells display transient adherens junctions. (B) Cluster cell migration of border cells in Drosophila melanogaster. Cells maintain tight adherens junctions while migrating with the leading cell in front exhibiting extensive protrusive behavior. These cells migrate toward the EGF/PVF-1 source. (C) Branching morphogenesis of Drosophila melanogaster trachea. While the leading cell migrates toward the source of Fgf, trailing cells form tube like structures. (D) Epithelial sheet migration-wound healing. Leading cells on either side of the wound migrate toward each other to close the wound. Leading cells extend filopodial protrusions toward each other. Follower cells extend cryptic lamellipodia underneath cells in front of them. Adherens junctions are maintained during migration.