FIGURE
Fig. 1
- ID
- ZDB-FIG-190723-2469
- Publication
- Kappel et al., 2017 - Store-Operated Ca2+ Entry as a Prostate Cancer Biomarker - a Riddle with Perspectives.
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Fig. 1
Activation of SOCE and TRPM4 as feedback mechanism for SOCE. Upon receptor stimulation, IP3 is produced and binds to the IP3 receptor. Subsequently, Ca2+ is released from intracellular Ca2+ stores. The decrease in Ca2+ in the ER results in the dissociation of Ca2+ from STIM1 proteins, which cluster and recruit and activate Orai1 channels in the plasma membrane that mediate SOCE. The increase in intracellular Ca2+ activates TRPM4. The Na+ influx via TRPM4 is a negative feedback mechanism for SOCE (please see text for details) |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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