Figure 3

Comparing relative central nervous system (CNS) gene expression for developmental and degenerative disease gene orthologs in zebrafish. Previously published in situ hybridization data was collected from the zebrafish model organism database (ZFIN.org). Expression level was scored for each gene proportionally from 0 to 3; 0, no expression; 1, expression; 2, moderate expression; and 3, high level of expression, (i.e., gene x showed expression in the telencephalon (1) at 12 hpf and comparatively high expression in the telencephalon (3) at 36 hpf). Zebrafish larvae illustrations were adapted from Kimmel et al. (1995). D, diencephalon; M, mesencephalon; R, rhombencephalon; T, telencephalon and SC, spinal cord (De Jonghe et al., 1997; Kudoh et al., 2001; Thisse et al., 2001; Wurst and Bally-Cuif, 2001; Groth et al., 2002; Rauch et al., 2003; Thisse and Thisse, 2004, 2005; Croushore et al., 2005; Imamura and Kishi, 2005; Meyer et al., 2005; Thompson et al., 2005; Yimlamai et al., 2005; Liu et al., 2006; Mendelsohn et al., 2006; Meyer and Smith, 2006; Cheng et al., 2007; George et al., 2007; Goruppi et al., 2007; Katsuyama et al., 2007; Patten et al., 2007; Anichtchik et al., 2008; Stuebe et al., 2008; Sun et al., 2008; Yoshida and Mishina, 2008; Zhou et al., 2008; Emond et al., 2009; Ferrante et al., 2009; Monnich et al., 2009; Patten and Ali, 2009; Titus et al., 2009; Wood et al., 2009; Appelbaum et al., 2010; Davey et al., 2010; Fassier et al., 2010; Rissone et al., 2010; Takada and Appel, 2010; Mapp et al., 2011; Yeh et al., 2011; Artuso et al., 2012; Dresner et al., 2012; Gomez et al., 2012; Imai et al., 2012; Mueller, 2012; Pujol-Martí et al., 2012; Xing et al., 2012; Yanicostas et al., 2012; Baraban et al., 2013; Campbell and Marlow, 2013; Haug et al., 2013; Ng et al., 2013; Recher et al., 2013; Suls et al., 2013; Vatine et al., 2013; Bernier et al., 2014; Garbarino et al., 2014; Housley et al., 2014; Hsieh et al., 2014; Galizia et al., 2015; Kozol et al., 2015; Wakayama et al., 2015).