FIGURE

Fig. 3

ID

ZDB-FIG-190723-2137

Publication

Brunt et al., 2017 - The function of endocytosis in Wnt signaling.

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

PCP signaling-regulated cell migration by endocytosis of adhesion plaques. Adhesion plaques serve as anchors to neighboring cells or substrates (1). Noncanonical Wnt signaling activates the internalization of the plaque components cadherin and protocadherin, predominantly in the rear of the cell (2). Cadherins are routed through the endocytic pathway from Rab5 early endosomes to Rab4/11 recycling endosomes (3). This allows for the assembly of new anchor points at the front of the cell. Cadherins are also routed for degradation to Rab7-positive endosomes and Lamp1 lysosomes (4). The differential rate between recycling and degradation determines the amount of Cadherin available for adhesion

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell. Mol. Life Sci.