FIGURE

Figure 1

ID

ZDB-FIG-190723-1438

Publication

Chrispijn et al., 2019 - Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development

Other Figures

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Figure 1

Zygotic rnf2 mutant zebrafish embryos show a pleiotropic phenotype. (a) Lateral view of wildtype embryos (left panel) and rnf2 mutant embryos (right panel) at 3 dpf. The rnf2 mutants show a pleiotropic phenotype, including motility problems, craniofacial defects (arrowheads), lack of pectoral fins, and a pronounced heart edema (arrowheads). Not all phenotypes are visible in the pictures. Scale bar = 1 mm. (b) Expression of tissue-specific markers was assessed by WISH at 3 dpf in wildtype and rnf2 mutant embryos. fabp2: intestinal marker, fabp10: liver marker, try: exocrine pancreas marker (arrowhead indicates pancreatic lobe), and myl7: cardiomyocyte marker. Scale bar is 200 µm.

Expression Data

Genes:	fabp2 fabp10a myl7 prss1
Fish:	TL rnf2^ibl31/ibl31 (TL)
Anatomical Terms:	cardiac muscle cell exocrine pancreas intestine liver
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rnf2^ibl31/ibl31 (TL)
Observed In:	cardiac muscle cell cranium exocrine pancreas intestine liver pectoral fin pericardium (all 7)
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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