FIGURE

Fig. 6

ID

ZDB-FIG-190723-1423

Publication

Chapman et al., 2019 - A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis

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Fig. 6

Zinc localization and SLC39 zinc transporter expression in CCM models. a Zinypr-1 detects zinc in the posterior cardinal vein (PCV) and caudal vein (CV) vasculature of wild type zebrafish 4 days post fertilization (dpf). b Zinc localization in the PCV and CV is lost in the absence of krit1/ccm1 4 dpf. The endothelial cell vasculature is marked in red, and zinc appears green (yellow overlay). cSLC39 zinc transporter expression in CCM lesion tissue from patients (human) and in brain microvasculature endothelial tissue (BMEC) of endothelial-specific knockout mice (BMEC Ccm1)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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