FIGURE

Fig. 6

ID
ZDB-FIG-190709-13
Publication
O'Connor et al., 2018 - Bypassing Glutamic Acid Decarboxylase 1 (Gad1) Induced Craniofacial Defects with a Photoactivatable Translation Blocker Morpholino
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Fig. 6

Knockdown of Gad1 causes jaw defects visible at 3 dpf (A) wild-type; (B) gad1b morphant; (C,D) BHQ-gad1b-ccMO; (E,F) CyHQ-gad1b-ccMO. (C,E) BHQ- and CyHQ-gad1b-ccMO injected embryos raised in the dark exhibit morphological development comparable to wild-type embryos. (B, D, F). BHQ- and CyHQ-gad1b-ccMO injected embryos raised in the light exhibit abnormal development of the presumptive lower jaw (region denoted by bracket) comparable to embryos injected with gad1b MOs; region includes Meckel’s cartilage. Scale bar in (A) applies to all panels.
Expression Data

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Knockdown Reagent:
Observed In:
Stage: Protruding-mouth

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ ACS Chem. Neurosci.
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